Question: How does the spindle checkpoint know that it's supposed to take one chromosome from each parent? For example, why doesn't it take two chromosomes from the father and two chromosomes from the mother and split?

Question: Can more than one microtubule attach to the same centromere?

Question: I have a question about the graph you showed regarding the likelihood of Down Syndrome with the age of the mother: if the woman had a child previously, are her chances the same? If they're lower, why is that?

Question: Down Syndrome shares some similarity with Alzheimer's Disease. What is that?

Question: Do you look at a protein level in the kinds of things you are doing?

Question: Are any animals ever born with Down Syndrome?

Question: So if 2% of new spores have a problem with segregating one of their chromosomes, does that mean that there really is a very high fraction of spores which probably have at least one chromosome?

Question: Early in your talk you showed two ways that things can go wrong. One was Down Syndrome; the other was cancer cells -- which is much more substantial. There are 80 chromosomes instead of one extra chromosome. How does the machinery fail there?